Cytokine-Driven Inflammation Targeting F Box Protein Fbxo3 To Control
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Targeting F box protein Fbxo3 to control cytokine-driven inflammation.
Cytokine-driven inflammation underlies the pathobiology of a wide array of infectious and immune-related disorders. The TNFR-associated factor (TRAF) proteins have a vital role in innate immunity by conveying signals from cell surface receptors to elicit transcriptional activation of genes encoding proinflammatory cytokines. We discovered that a ubiquitin E3 ligase F box component, termed Fbxo3...
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تاریخ انتشار 2013